For research use only. Not for therapeutic Use.
MKI-1（Cat No.:I044659）is a small-molecule inhibitor that targets mitogen-activated protein kinase-interacting kinases (MNKs), particularly MNK1 and MNK2, which regulate the phosphorylation of eIF4E, a key factor in cap-dependent mRNA translation. By inhibiting MNK activity, MKI-1 suppresses eIF4E-driven oncogenic translation, affecting the expression of cancer-related proteins involved in proliferation, survival, and metastasis. It is a valuable research tool for studying the role of translational control in cancer biology and exploring therapeutic strategies in malignancies with dysregulated MNK-eIF4E signaling. MKI-1 is useful in both in vitro and preclinical cancer models.
| CAS Number | 1190277-80-5 |
| Synonyms | N-(1H-benzimidazol-2-yl)-3-pyrrol-1-ylbenzamide |
| Molecular Formula | C18H14N4O |
| Purity | ≥95% |
| IUPAC Name | N-(1H-benzimidazol-2-yl)-3-pyrrol-1-ylbenzamide |
| InChI | InChI=1S/C18H14N4O/c23-17(21-18-19-15-8-1-2-9-16(15)20-18)13-6-5-7-14(12-13)22-10-3-4-11-22/h1-12H,(H2,19,20,21,23) |
| InChIKey | XKDZPQAMBMLCDQ-UHFFFAOYSA-N |
| SMILES | C1=CC=C2C(=C1)NC(=N2)NC(=O)C3=CC(=CC=C3)N4C=CC=C4 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
