For research use only. Not for therapeutic Use.
MK-6884（Cat No.:I032394）is a potent, selective positive allosteric modulator (PAM) of the muscarinic acetylcholine M4 receptor (M4R), a G protein–coupled receptor involved in regulating dopaminergic and cholinergic signaling in the central nervous system. By enhancing M4R activity in the presence of acetylcholine, MK-6884 modulates neural circuits linked to motor control, cognition, and psychiatric disorders. It shows promise in treating schizophrenia, Parkinson’s disease, and other neuropsychiatric conditions. MK-6884 is a valuable research tool for studying M4R pharmacology and holds therapeutic potential for developing targeted CNS drugs with improved specificity and tolerability.
| CAS Number | 2102194-04-5 |
| Synonyms | 5-[1-[(1-methylcyclopentyl)methyl]pyrazol-4-yl]-6-(2-methyl-3-oxo-1H-isoindol-5-yl)pyridine-2-carbonitrile |
| Molecular Formula | C25H25N5O |
| Purity | ≥95% |
| IUPAC Name | 5-[1-[(1-methylcyclopentyl)methyl]pyrazol-4-yl]-6-(2-methyl-3-oxo-1H-isoindol-5-yl)pyridine-2-carbonitrile |
| InChI | InChI=1S/C25H25N5O/c1-25(9-3-4-10-25)16-30-15-19(13-27-30)21-8-7-20(12-26)28-23(21)17-5-6-18-14-29(2)24(31)22(18)11-17/h5-8,11,13,15H,3-4,9-10,14,16H2,1-2H3 |
| InChIKey | PREPVVXBTJBVOZ-UHFFFAOYSA-N |
| SMILES | CC1(CCCC1)CN2C=C(C=N2)C3=C(N=C(C=C3)C#N)C4=CC5=C(CN(C5=O)C)C=C4 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
