MK-28（Cat No.:I044681）is a small-molecule activator of protein kinase RNA-like endoplasmic reticulum kinase (PERK), a key regulator in the unfolded protein response (UPR) pathway. By enhancing PERK activity, MK-28 helps restore cellular homeostasis under endoplasmic reticulum (ER) stress conditions by promoting adaptive signaling, including phosphorylation of eIF2α and attenuation of global protein synthesis. It has shown neuroprotective effects in preclinical models of neurodegenerative diseases such as Parkinson’s and ALS, where ER stress contributes to pathology. MK-28 holds promise as a therapeutic agent for modulating UPR signaling in stress-related disorders.