MK-2295(CAT: I008055) is a potent antagonist of the transient receptor potential vanilloid 1 (TRPV1) channel. TRPV1 antagonists have gained attention as potential analgesic agents for the treatment of chronic pathological pain. MK-2295 belongs to this class of compounds and exhibits strong inhibitory activity against the TRPV1 receptor. The development of TRPV1 antagonists has been actively pursued by the pharmaceutical industry due to the need for effective treatments for chronic pain conditions.
| Catalog Number | I008055 |
| CAS Number | 878811-00-8 (free base); 1855897-95-8 (mesylate salt). |
| Synonyms | MK-2295; MK2295; MK 2295.;6-((R)-4-(6-(4-fluorophenyl)-2-((R)-2-methylpyrrolidin-1-yl)pyrimidin-4-yl)-3-methylpiperazin-1-yl)-5-methylnicotinic acid |
| Molecular Formula | C27H31FN6O2 |
| Purity | 95% |
| Target | TRPV1 antagonist |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| SMILES | O=C(C1=CC(C)=C(N2C[C@@H](C)N(C3=NC(N4[C@H](C)CCC4)=NC(C5=CC=C(F)C=C5)=C3)CC2)N=C1)O |
| Reference | </br>1: Kym PR, Kort ME, Hutchins CW. Analgesic potential of TRPV1 antagonists.</br> Biochem Pharmacol. 2009 Aug 1;78(3):211-6. doi: 10.1016/j.bcp.2009.02.014. Epub</br> 2009 Mar 5. PubMed PMID: 19481638. |
