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MK-2295 - CAS 878811-00-8 (free base); 1855897-95-8 (mesylate salt).

MK-2295(CAT: I008055) is a potent antagonist of the transient receptor potential vanilloid 1 (TRPV1) channel. TRPV1 antagonists have gained attention as potential analgesic agents for the treatment of chronic pathological pain. MK-2295 belongs to this class of compounds and exhibits strong inhibitory activity against the TRPV1 receptor. The development of TRPV1 antagonists has been actively pursued by the pharmaceutical industry due to the need for effective treatments for chronic pain conditions.

Catalog Number: I008055

CAS Number: 878811-00-8 (free base); 1855897-95-8 (mesylate salt).

Molecular Formula: C27H31FN6O2

Molecular Weight:490.5834

Purity: ≥95%

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Synonym

SynonymsMK-2295; MK2295; MK 2295.;6-((R)-4-(6-(4-fluorophenyl)-2-((R)-2-methylpyrrolidin-1-yl)pyrimidin-4-yl)-3-methylpiperazin-1-yl)-5-methylnicotinic acid

Property

Molecular Formula: C27H31FN6O2
Molecular Weight490.5834
Target:TRPV1 antagonist
SolubilitySoluble in DMSO, not in water
Purity≥95%
Storage0 - 4 °C for short term, or -20 °C for long term

Computed Descriptor

SMILESO=C(C1=CC(C)=C(N2C[C@@H](C)N(C3=NC(N4[C@H](C)CCC4)=NC(C5=CC=C(F)C=C5)=C3)CC2)N=C1)O