For research use only. Not for therapeutic Use.
MK-0493(CAT: I008009) is a potent, orally active, and selective agonist of the melanocortin receptor 4 (MC4R). This small-molecule modulator is widely studied for its role in regulating appetite and energy homeostasis. By activating MC4R, MK-0493 demonstrates significant reductions in energy intake, making it a valuable tool for exploring therapeutic approaches to obesity, metabolic syndrome, and related endocrinological disorders. Its receptor selectivity allows researchers to dissect central melanocortin signaling pathways with high precision. MK-0493 serves as an important reference compound in metabolic disease research, supporting the development of next-generation treatments targeting energy balance and weight management.
| CAS Number | 455956-93-1 |
| Synonyms | N-[(1S)-1-[2-[1-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]piperidin-4-yl]-5-chlorophenyl]ethyl]acetamide |
| Molecular Formula | C30H38ClF2N3O2 |
| Purity | ≥95% |
| IUPAC Name | N-[(1S)-1-[2-[1-[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl]piperidin-4-yl]-5-chlorophenyl]ethyl]acetamide |
| InChI | InChI=1S/C30H38ClF2N3O2/c1-18(34-19(2)37)25-14-21(31)6-8-23(25)20-10-12-35(13-11-20)29(38)27-17-36(30(3,4)5)16-26(27)24-9-7-22(32)15-28(24)33/h6-9,14-15,18,20,26-27H,10-13,16-17H2,1-5H3,(H,34,37)/t18-,26-,27+/m0/s1 |
| InChIKey | ZCWVNCMFYHPHCX-RHLLTPQKSA-N |
| SMILES | CC(C1=C(C=CC(=C1)Cl)C2CCN(CC2)C(=O)C3CN(CC3C4=C(C=C(C=C4)F)F)C(C)(C)C)NC(=O)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
