Mitochondrial respiration-IN-1 hydrobromide

• CAT Number: I045456
• Molecular Formula: C26H26Br2NO2PS
• Molecular Weight: 607.34
• Purity: ≥95%
• Synonyms: [2-[2-(4-methyl-1,3-thiazol-5-yl)ethoxy]-2-oxoethyl]-triphenylphosphanium;bromide;hydrobromide
• InChI: InChI=1S/C26H25NO2PS.2BrH/c1-21-25(31-20-27-21)17-18-29-26(28)19-30(22-11-5-2-6-12-22,23-13-7-3-8-14-23)24-15-9-4-10-16-24;;/h2-16,20H,17-19H2,1H3;2*1H/q+1;;/p-1
• InChIKey: XJBKKHMZGIBMGV-UHFFFAOYSA-M
• SMILES: CC1=C(SC=N1)CCOC(=O)C[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4.Br.[Br-]

Mitochondrial respiration-IN-1 hydrobromide (Cat No.: I045456) is a small-molecule inhibitor that selectively targets components of the mitochondrial electron transport chain, disrupting oxidative phosphorylation and ATP production. By impairing mitochondrial respiration, it alters cellular energy metabolism and can induce metabolic stress, making it a valuable tool for studying bioenergetics, mitochondrial dysfunction, and metabolic reprogramming in diseases such as cancer and neurodegeneration. The hydrobromide salt form enhances stability and solubility. This compound is widely used in biochemical, pharmacological, and cell biology research to probe mitochondrial function.

Reference

[1]. James P. Collman, et al. Reducing Platelet Activation, Aggregation and Platelet-Stimulated Thrombosis or Blood Coagulation by Reducing Mitochondrial Respiration. US20110301180A1.