For research use only. Not for therapeutic Use.
Mito-apocynin (C2)(CAT: I016213) is a mitochondria-targeted analog of apocynin, linked to a triphenylphosphonium (TPP⁺) cation via a two-carbon alkyl chain. This structural modification facilitates mitochondrial accumulation, enabling selective inhibition of NADPH oxidase–mediated reactive oxygen species (ROS) generation at the organelle level. By attenuating oxidative stress, Mito-apocynin (C2) demonstrates protective effects in models of neurodegeneration, cardiovascular injury, and inflammation. Compared with longer-chain derivatives, the shorter C2 linker alters lipophilicity and cellular uptake, providing researchers with an important tool for studying chain-length–dependent pharmacological behavior. Mito-apocynin (C2) is highly valuable in redox biology, mitochondrial dysfunction, and metabolic disease research.
| CAS Number | 1254044-41-1 |
| Synonyms | 2-[(4-hydroxy-3-methoxybenzoyl)amino]ethyl-triphenylphosphanium;bromide |
| Molecular Formula | C28H27BrNO3P |
| Purity | ≥95% |
| IUPAC Name | 2-[(4-hydroxy-3-methoxybenzoyl)amino]ethyl-triphenylphosphanium;bromide |
| InChI | InChI=1S/C28H26NO3P.BrH/c1-32-27-21-22(17-18-26(27)30)28(31)29-19-20-33(23-11-5-2-6-12-23,24-13-7-3-8-14-24)25-15-9-4-10-16-25;/h2-18,21H,19-20H2,1H3,(H-,29,30,31);1H |
| InChIKey | VCBKDUGPZYICTB-UHFFFAOYSA-N |
| SMILES | COC1=C(C=CC(=C1)C(=O)NCC[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)O.[Br-] |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
