Mifamurtide TFA

• CAT Number: I044693
• Molecular Formula: C61H110F3N6O21P
• Molecular Weight: 1351.52
• Purity: ≥95%
• Synonyms: [(2R)-3-[2-[[(2S)-2-[[(4R)-4-[[(2S)-2-[[(2R)-2-[(2R,3R,4R,5R)-2-acetamido-4,5,6-trihydroxy-1-oxohexan-3-yl]oxypropanoyl]amino]propanoyl]amino]-5-amino-5-oxopentanoyl]amino]propanoyl]amino]ethoxy-hydroxyphosphoryl]oxy-2-hexadecanoyloxypropyl] hexadecanoate;2,2,2-trifluoroacetic acid
• InChI: InChI=1S/C59H109N6O19P.C2HF3O2/c1-7-9-11-13-15-17-19-21-23-25-27-29-31-33-52(71)80-41-47(84-53(72)34-32-30-28-26-24-22-20-18-16-14-12-10-8-2)42-82-85(78,79)81-38-37-61-57(75)43(3)62-51(70)36-35-48(56(60)74)65-58(76)44(4)63-59(77)45(5)83-55(54(73)50(69)40-67)49(39-66)64-46(6)68;3-2(4,5)1(6)7/h39,43-45,47-50,54-55,67,69,73H,7-38,40-42H2,1-6H3,(H2,60,74)(H,61,75)(H,62,70)(H,63,77)(H,64,68)(H,65,76)(H,78,79);(H,6,7)/t43-,44-,45+,47+,48+,49-,50+,54+,55+;/m0./s1
• InChIKey: SXGUMFWBRIKGMK-XNLRRNFISA-N
• SMILES: CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(O)OCCNC(=O)[C@H](C)NC(=O)CC[C@H](C(=O)N)NC(=O)[C@H](C)NC(=O)[C@@H](C)O[C@H]([C@H](C=O)NC(=O)C)[C@@H]([C@@H](CO)O)O)OC(=O)CCCCCCCCCCCCCCC.C(=O)(C(F)(F)F)O

Mifamurtide TFA (Cat No.:I044693) is an immunomodulatory agent that mimics muramyl dipeptide, a component of bacterial cell walls. It activates the innate immune system by stimulating monocytes and macrophages through the NOD2 receptor, leading to the release of pro-inflammatory cytokines and enhanced anti-tumor activity. Mifamurtide TFA is primarily used in the treatment of osteosarcoma, particularly in pediatric and adolescent patients, to reduce the risk of metastasis following chemotherapy. The TFA salt form improves solubility and formulation stability, supporting its clinical utility in cancer immunotherapy.