MI-463 - CAS 1628317-18-9

MI-463 is a potent menin-MLL inhibitor with IC50=15.3 nM and Kd=9.9 nM. MI-463 shows its profound effects in MLL leukemia cells and substantial survival benefit in mouse models of MLL leukemia. Pharmacologic inhibition of the menin-MLL interaction represents an effective treatment for MLL leukemias in vivo and provide advanced molecular scaffold for clinical lead identification. Chromosomal translocations affecting mixed lineage leukemia gene (MLL) result in acute leukemias resistant to therapy. The leukemogenic activity of MLL fusion proteins is dependent on their interaction with menin, providing basis for therapeutic intervention.

Catalog Number: I007981

CAS Number: 1628317-18-9

PubChem Substance ID:355048751

Molecular Formula: C24H23F3N6S

Molecular Weight:484.5452

Purity: ≥95%

* For research use only. Not for human or veterinary use.


SynonymsMI-463; MI 463; MI463.;4-methyl-5-((4-((6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)methyl)-1H-indole-2-carbonitrile


Molecular Formula: C24H23F3N6S
Molecular Weight484.5452
Target:menin-MLL inhibitor
SolubilitySoluble in DMSO, not in water
Storage0 - 4 °C for short term, or -20 °C for long term
MDL15.3 Nm
IC5015.3 nM

Computed Descriptor