For research use only. Not for therapeutic Use.
MI-2-2（Cat No.:I032245）is a potent, selective small-molecule inhibitor of menin, a scaffold protein that interacts with MLL (mixed-lineage leukemia) fusion proteins involved in leukemogenesis. By disrupting the menin–MLL interaction, MI-2-2 impairs the transcriptional activity of MLL fusion oncogenes, leading to reduced expression of leukemogenic target genes such as HOXA9 and MEIS1. It has shown significant efficacy in preclinical models of MLL-rearranged leukemia, inducing cell differentiation and apoptosis. MI-2-2 is a valuable research tool for studying epigenetic regulation in cancer and developing targeted therapies for MLL-related hematologic malignancies.
| CAS Number | 1454920-20-7 |
| Synonyms | 4-[4-(5,5-dimethyl-4H-1,3-thiazol-2-yl)piperazin-1-yl]-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidine |
| Molecular Formula | C17H20F3N5S2 |
| Purity | ≥95% |
| IUPAC Name | 4-[4-(5,5-dimethyl-4H-1,3-thiazol-2-yl)piperazin-1-yl]-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidine |
| InChI | InChI=1S/C17H20F3N5S2/c1-16(2)9-21-15(27-16)25-5-3-24(4-6-25)13-12-7-11(8-17(18,19)20)26-14(12)23-10-22-13/h7,10H,3-6,8-9H2,1-2H3 |
| InChIKey | SFDROHXKTATJBI-UHFFFAOYSA-N |
| SMILES | CC1(CN=C(S1)N2CCN(CC2)C3=C4C=C(SC4=NC=N3)CC(F)(F)F)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
