For research use only. Not for therapeutic Use.
mGluR5 antagonist-1(CAT: I040581) is a potent and selective small-molecule inhibitor of metabotropic glutamate receptor 5 (mGluR5), a G-protein-coupled receptor involved in excitatory neurotransmission, synaptic plasticity, and neuroinflammation. By blocking mGluR5 activity, this compound modulates downstream signaling pathways associated with various central nervous system disorders, including anxiety, depression, fragile X syndrome, and Parkinson’s disease. mGluR5 antagonist-1 offers high receptor selectivity and brain penetrance, making it suitable for neuropharmacological studies in both in vitro and in vivo models. It is a valuable research tool for elucidating glutamatergic dysfunction and evaluating novel therapeutic strategies targeting mGluR5-mediated pathways.
| CAS Number | 2761424-76-2 |
| Synonyms | N-(4-methoxyphenyl)-7-methyl-4-(2-phenylethynyl)pyrrolo[2,3-d]pyrimidine-6-carboxamide |
| Molecular Formula | C23H18N4O2 |
| Purity | ≥95% |
| IUPAC Name | N-(4-methoxyphenyl)-7-methyl-4-(2-phenylethynyl)pyrrolo[2,3-d]pyrimidine-6-carboxamide |
| InChI | InChI=1S/C23H18N4O2/c1-27-21(23(28)26-17-9-11-18(29-2)12-10-17)14-19-20(24-15-25-22(19)27)13-8-16-6-4-3-5-7-16/h3-7,9-12,14-15H,1-2H3,(H,26,28) |
| InChIKey | OIYWWKBIBPZHKJ-UHFFFAOYSA-N |
| SMILES | CN1C(=CC2=C(N=CN=C21)C#CC3=CC=CC=C3)C(=O)NC4=CC=C(C=C4)OC |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
