Metofluthrin

• CAT Number: M002181
• CAS Number: 240494-70-6
• Molecular Formula: C18H20F4O3
• Molecular Weight: 360.34
• Purity: ≥95%
• Storage: Store at -20C
• IUPAC Name: [2,3,5,6-tetrafluoro-4-(methoxymethyl)phenyl]methyl 2,2-dimethyl-3-[(E)-prop-1-enyl]cyclopropane-1-carboxylate
• InChI: InChI=1S/C18H20F4O3/c1-5-6-11-12(18(11,2)3)17(23)25-8-10-15(21)13(19)9(7-24-4)14(20)16(10)22/h5-6,11-12H,7-8H2,1-4H3/b6-5+
• InChIKey: KVIZNNVXXNFLMU-AATRIKPKSA-N
• SMILES: CC=CC1C(C1(C)C)C(=O)OCC2=C(C(=C(C(=C2F)F)COC)F)F

Metofluthrin（Cat No.:M002181）, is a synthetic pyrethroid insecticide commonly used in various mosquito repellent and control products. It is known for its strong mosquito-repelling properties and low toxicity to humans and animals. Metofluthrin works by disrupting the nervous system of insects, causing paralysis and ultimately leading to their death. It is used in various forms, such as coils, mats, and liquids, for both residential and commercial purposes to control mosquito populations. Due to its effectiveness in repelling and eliminating mosquitoes, it is a key component in the fight against mosquito-borne diseases like malaria and dengue fever in many parts of the world.

Reference

1: Buhagiar TS, Devine GJ, Ritchie SA. Effects of sublethal exposure to metofluthrin on the fitness of Aedes aegypti in a domestic setting in Cairns, Queensland. Parasit Vectors. 2017 May 31;10(1):274. doi: 10.1186/s13071-017-2220-7. PubMed PMID: 28569175; PubMed Central PMCID: PMC5452423.
2: Buhagiar TS, Devine GJ, Ritchie SA. Metofluthrin: investigations into the use of a volatile spatial pyrethroid in a global spread of dengue, chikungunya and Zika viruses. Parasit Vectors. 2017 May 30;10(1):270. doi: 10.1186/s13071-017-2219-0. PubMed PMID: 28558804; PubMed Central PMCID: PMC5450184.
3: Darbro JM, Muzari MO, Giblin A, Adamczyk RM, Ritchie SA, Devine GJ. Reducing biting rates of Aedes aegypti with metofluthrin: investigations in time and space. Parasit Vectors. 2017 Feb 7;10(1):69. doi: 10.1186/s13071-017-2004-0. PubMed PMID: 28173824; PubMed Central PMCID: PMC5297195.
4: Abe J, Nagahori H, Tarui H, Tomigahara Y, Isobe N. Metabolism of metofluthrin in rats: I. Identification of metabolites. Xenobiotica. 2017 Feb 5:1-13. doi: 10.1080/00498254.2017.1283718. [Epub ahead of print] PubMed PMID: 28092216.
5: Ponlawat A, Kankaew P, Chanaimongkol S, Pongsiri A, Richardson JH, Evans BP. Semi-Field Evaluation of Metofluthrin-Impregnated Nets on Host-Seeking Aedes aegypti and Anopheles dirus. J Am Mosq Control Assoc. 2016 Jun;32(2):130-8. doi: 10.2987/moco-32-02-130-138.1. PubMed PMID: 27280351.
6: Charlwood JD, Nenhep S, Protopopoff N, Sovannaroth S, Morgan JC, Hemingway J. Effects of the spatial repellent metofluthrin on landing rates of outdoor biting anophelines in Cambodia, Southeast Asia. Med Vet Entomol. 2016 Jun;30(2):229-34. doi: 10.1111/mve.12168. Epub 2016 Mar 15. PubMed PMID: 26991881.
7: Bibbs CS, Xue RD. OFF! Clip-on Repellent Device With Metofluthrin Tested on Aedes aegypti (Diptera: Culicidae) for Mortality at Different Time Intervals and Distances. J Med Entomol. 2016 Mar;53(2):480-3. PubMed PMID: 26668103.