For research use only. Not for therapeutic Use.
Methyltetrazine-PEG8-acid(CAT: I016548) is a versatile bioorthogonal linker featuring a methyltetrazine reactive handle tethered to a terminal carboxylic acid by an eight-unit PEG spacer. The methyltetrazine enables ultrafast inverse-electron-demand Diels–Alder (IEDDA) reactions with strained dienophiles (e.g., trans-cyclooctene) for rapid, catalyst-free labeling, while the carboxylic acid offers a convenient site for amide coupling to amines. The PEG8 spacer improves aqueous solubility, reduces steric hindrance, and enhances flexibility, increasing accessibility of both functional groups. Ideal for site-specific protein labeling, imaging probe synthesis, antibody–drug conjugates, and modular bioconjugation workflows where speed, selectivity, and solubility matter.
CAS Number | 2183440-33-5 |
Synonyms | 3-[2-[2-[2-[2-[2-[2-[2-[2-[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid |
Molecular Formula | C28H44N4O11 |
Purity | ≥95% |
IUPAC Name | 3-[2-[2-[2-[2-[2-[2-[2-[2-[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid |
InChI | InChI=1S/C28H44N4O11/c1-24-29-31-28(32-30-24)25-2-4-26(5-3-25)43-23-22-42-21-20-41-19-18-40-17-16-39-15-14-38-13-12-37-11-10-36-9-8-35-7-6-27(33)34/h2-5H,6-23H2,1H3,(H,33,34) |
InChIKey | JDJSAIBRQJQXLA-UHFFFAOYSA-N |
SMILES | CC1=NN=C(N=N1)C2=CC=C(C=C2)OCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)O |
Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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