Methylphenidate Carboxylic Acid

• CAT Number: R045730
• CAS Number: 19395-40-5
• Molecular Formula: C13H18ClNO2
• Molecular Weight: 255.74
• Purity: ≥95%
• Synonyms: α-Phenyl-2-piperidineacetic Acid Hydrochloride; Ritalinic Acid Hydrochloride; USP Methylphenidate Related Compound A
• Storage: -20°C
• IUPAC Name: 2-phenyl-2-piperidin-2-ylacetic acid;hydrochloride
• InChI: InChI=1S/C13H17NO2.ClH/c15-13(16)12(10-6-2-1-3-7-10)11-8-4-5-9-14-11;/h1-3,6-7,11-12,14H,4-5,8-9H2,(H,15,16);1H
• InChIKey: SCUMDQFFZZGUQY-UHFFFAOYSA-N
• SMILES: C1CCNC(C1)C(C2=CC=CC=C2)C(=O)O.Cl

Methylphenidate carboxylic acid（Cat No.:R045730）is the primary inactive metabolite of methylphenidate, a central nervous system stimulant commonly used to treat ADHD and narcolepsy. Formed via hydrolysis by carboxylesterase enzymes, it lacks pharmacological activity at dopamine and norepinephrine transporters. Its chemical structure includes a carboxylic acid group replacing the ester moiety of the parent compound. This metabolite is water-soluble and excreted primarily in urine. Though biologically inactive, methylphenidate carboxylic acid is important in pharmacokinetic studies, drug metabolism profiling, and therapeutic monitoring of methylphenidate-based medications in clinical and forensic contexts.