Methylnitrosourea

• CAT Number: R006722
• CAS Number: 684-93-5
• Molecular Formula: C2H5N3O2
• Molecular Weight: 103.081
• Purity: ≥95%
• Storage: -20°C
• Related CAS: 820-60-0
• IUPAC Name: 1-methyl-1-nitrosourea
• InChI: InChI=1S/C2H5N3O2/c1-5(4-7)2(3)6/h1H3,(H2,3,6)
• InChIKey: ZRKWMRDKSOPRRS-UHFFFAOYSA-N
• SMILES: CN(C(=O)N)N=O

N-Nitroso-n-methylurea(CAS 684-93-5) has been studied in mutagenicity and genetics studies and for use as a cancer chemotherapy agent. Tumors have been reported in the offspring of animals treated with N-nitroso-n-methylurea during their pregnancy. 

Reference

1.IARC Monogr Eval Carcinog Risk Chem Man. 1978 May;17:227-55.N-nitroso-n-methylurea.PMID: 355099 [Indexed for MEDLINE]
2.Cha, Rita S., William G. Thilly, and Helmut Zarbl. "N-nitroso-N-methylurea-induced rat mammary tumors arise from cells with preexisting oncogenic Hras1 gene mutations." Proceedings of the National Academy of Sciences 91.9 (1994): 3749-3753.
3.Pollard, Morris, and Phyllis H. Luckert. "Production of autochthonous prostate cancer in Lobund-Wistar rats by treatments with N-nitroso-N-methylurea and testosterone." Journal of the National Cancer Institute 77.2 (1986): 583-587.