Methyl 5-chloro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylate

• CAT Number: L043302
• CAS Number: 91447-90-4
• Molecular Formula: C6H5ClN2O4
• Molecular Weight: 204.57
• Purity: ≥95%
• IUPAC Name: methyl 5-chloro-2,4-dioxo-1H-pyrimidine-6-carboxylate
• InChI: InChI=1S/C6H5ClN2O4/c1-13-5(11)3-2(7)4(10)9-6(12)8-3/h1H3,(H2,8,9,10,12)
• InChIKey: XDXHOMYOYYIQHJ-UHFFFAOYSA-N

Methyl 5-chloro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylate(CAT: L043302) is a chlorinated barbituric acid derivative featuring a methyl ester at the 4-position and electron-withdrawing groups that enhance its reactivity. This compound is commonly used as an intermediate in the synthesis of heterocycles, pharmaceutical candidates, and agrochemicals. Its pyrimidine-based scaffold mimics biologically relevant nucleobase analogs, making it particularly attractive for antiviral, anticancer, and CNS-targeted research. The 5-chloro substitution enables selective halogen-based transformations, including nucleophilic substitution and cross-coupling. Supplied at high purity, this versatile reagent supports medicinal chemistry, structure–activity relationship (SAR) studies, and the design of small-molecule libraries for drug discovery.