Methoctramine tetrahydrochloride

• CAT Number: M010557
• CAS Number: 104807-46-7
• Molecular Formula: C36H66Cl4N4O2
• Molecular Weight: 728.75
• Purity: ≥95%
• Synonyms: N,N’-bis[6-[(2-methoxyphenyl)methylamino]hexyl]octane-1,8-diamine;tetrahydrochloride
• InChI: InChI=1S/C36H62N4O2.4ClH/c1-41-35-23-13-11-21-33(35)31-39-29-19-9-7-17-27-37-25-15-5-3-4-6-16-26-38-28-18-8-10-20-30-40-32-34-22-12-14-24-36(34)42-2;;;;/h11-14,21-24,37-40H,3-10,15-20,25-32H2,1-2H3;4*1H
• InChIKey: CDKGGOUDHGSFAF-UHFFFAOYSA-N
• SMILES: COC1=CC=CC=C1CNCCCCCCNCCCCCCCCNCCCCCCNCC2=CC=CC=C2OC.Cl.Cl.Cl.Cl

Methoctramine tetrahydrochloride (Cat No.: M010557) is a selective muscarinic M2 receptor antagonist widely used in cardiovascular and neuropharmacology research. By blocking M2 receptors, it prevents acetylcholine-mediated inhibition of adenylate cyclase, thereby enhancing cardiac contractility and heart rate. Methoctramine is also applied in studies of parasympathetic regulation, smooth muscle function, and central cholinergic pathways. The tetrahydrochloride salt improves solubility and stability, making it suitable for experimental applications. It serves as a valuable tool for exploring muscarinic receptor pharmacology, cardiac physiology, and drug discovery.

Reference

[1]. Jaiswal N, et, al. Methoctramine, a cardioselective antagonist: muscarinic receptor mediating prostaglandin synthesis in isolated rabbit heart. Eur J Pharmacol. 1991 Jan 3;192(1):63-70.
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[2]. Watson N, et, al. Actions of methoctramine, a muscarinic M2 receptor antagonist, on muscarinic and nicotinic cholinoceptors in guinea-pig airways in vivo and in vitro. Br J Pharmacol. 1992 Jan;105(1):107-12.
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[3]. Wess J, et, al. Methoctramine selectively blocks cardiac muscarinic M2 receptors in vivo. Naunyn Schmiedebergs Arch Pharmacol. 1988 Sep;338(3):246-9.
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