Methimazole

• CAT Number: A000359
• CAS Number: 60-56-0
• Molecular Formula: C4H6N2S
• Molecular Weight: 114.17
• Purity: ≥95%
• Synonyms: Thiamazole; 60-56-0; Tapazole; 2-Mercapto-1-methylimidazole; 1-Methylimidazole-2-thiol
• Target: Thyroid Peroxidase Inhibitor
• Storage: -20°C
• InChI: 1S/C4H6N2S/c1-6-3-2-5-4(6)7/h2-3H,1H3,(H,5,7)
• InChIKey: PMRYVIKBURPHAH-UHFFFAOYSA-N
• SMILES: CN1C=CNC1=S

Methimazole (Cat No.: A000359) is an antithyroid medication used to treat hyperthyroidism, particularly in conditions like Graves’ disease. It works by inhibiting the enzyme thyroid peroxidase, which is essential for the synthesis of thyroid hormones (T3 and T4). Methimazole helps normalize thyroid function by reducing excessive hormone production. It is administered orally and preferred for long-term management due to its once-daily dosing and lower risk of liver toxicity compared to propylthiouracil. Common side effects include rash, joint pain, and, rarely, agranulocytosis.

Reference

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