Methaneseleninic Acid

• CAT Number: M002834
• CAS Number: 28274-57-9
• Molecular Formula: CH4O2Se
• Molecular Weight: 127.012
• Purity: ≥95%
• Synonyms: METHYLSELENINIC ACID;METHANESELENINIC ACID;methylselenic acid;NSC 243621;NSC 244776;Methaneseleninic acid 95%
• Storage: Store at -20°C
• IUPAC Name: methaneseleninic acid
• InChI: InChI=1S/CH4O2Se/c1-4(2)3/h1H3,(H,2,3)
• InChIKey: UEQANLFPOFICBH-UHFFFAOYSA-N
• SMILES: C[Se](=O)O

Reference

1: Singh CK, Ndiaye MA, Siddiqui IA, Nihal M, Havighurst T, Kim K, Zhong W,
Mukhtar H, Ahmad N. Methaneseleninic acid and γ-Tocopherol combination inhibits
prostate tumor growth in Vivo in a xenograft mouse model. Oncotarget. 2014 Jun
15;5(11):3651-61. PubMed PMID: 25004451; PubMed Central PMCID: PMC4116510.

2: Snider G, Grout L, Ruggles EL, Hondal RJ. Methaneseleninic acid is a substrate
for truncated mammalian thioredoxin reductase: implications for the catalytic
mechanism and redox signaling. Biochemistry. 2010 Dec 7;49(48):10329-38. doi:
10.1021/bi101130t. Epub 2010 Nov 10. PubMed PMID: 21038895; PubMed Central PMCID:
PMC3018153.

3: Qi Y, Fu X, Xiong Z, Zhang H, Hill SM, Rowan BG, Dong Y. Methylseleninic acid
enhances paclitaxel efficacy for the treatment of triple-negative breast cancer.
PLoS One. 2012;7(2):e31539. doi: 10.1371/journal.pone.0031539. Epub 2012 Feb 14.
PubMed PMID: 22348099; PubMed Central PMCID: PMC3279411.

4: Tarrado-Castellarnau M, Cortés R, Zanuy M, Tarragó-Celada J, Polat IH, Hill R,
Fan TW, Link W, Cascante M. Methylseleninic acid promotes antitumour effects via
nuclear FOXO3a translocation through Akt inhibition. Pharmacol Res. 2015
Dec;102:218-34. doi: 10.1016/j.phrs.2015.09.009. Epub 2015 Nov 4. PubMed PMID:
26375988; PubMed Central PMCID: PMC4850087.

5: Liu M, Hu C, Xu Q, Chen L, Ma K, Xu N, Zhu H. Methylseleninic acid activates
Keap1/Nrf2 pathway via up-regulating miR-200a in human oesophageal squamous cell
carcinoma cells. Biosci Rep. 2015 Sep 4;35(5). pii: e00256. doi:
10.1042/BSR20150092. PubMed PMID: 26341629; PubMed Central PMCID: PMC4613709.