For research use only. Not for therapeutic Use.
Menin-MLL Inhibitor 20（Cat No.:I044327）is a potent and selective small-molecule inhibitor that disrupts the interaction between menin and mixed-lineage leukemia (MLL) fusion proteins. This interaction plays a critical role in leukemogenesis, especially in MLL-rearranged acute leukemias. By blocking the menin-MLL complex, Inhibitor 20 effectively downregulates HOXA9 and MEIS1 gene expression, reducing leukemic cell proliferation. It has demonstrated significant anti-tumor activity in preclinical models, making it a valuable tool in epigenetic and hematologic cancer research. Menin-MLL Inhibitor 20 supports studies focused on targeted therapy development in aggressive leukemia subtypes.
| CAS Number | 2448173-47-3 |
| Synonyms | tert-butyl N-[(3R)-1-[[2-[[4-(4-morpholin-4-yl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl]carbamoyl]pyridin-4-yl]methyl]piperidin-3-yl]carbamate |
| Molecular Formula | C33H40N8O4 |
| Purity | ≥95% |
| IUPAC Name | tert-butyl N-[(3R)-1-[[2-[[4-(4-morpholin-4-yl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl]carbamoyl]pyridin-4-yl]methyl]piperidin-3-yl]carbamate |
| InChI | InChI=1S/C33H40N8O4/c1-33(2,3)45-32(43)38-25-5-4-12-40(20-25)19-22-10-11-34-28(17-22)31(42)37-24-8-6-23(7-9-24)27-18-26-29(39-27)35-21-36-30(26)41-13-15-44-16-14-41/h6-11,17-18,21,25H,4-5,12-16,19-20H2,1-3H3,(H,37,42)(H,38,43)(H,35,36,39)/t25-/m1/s1 |
| InChIKey | MPFHTFMFYAODPE-RUZDIDTESA-N |
| SMILES | CC(C)(C)OC(=O)N[C@@H]1CCCN(C1)CC2=CC(=NC=C2)C(=O)NC3=CC=C(C=C3)C4=CC5=C(N4)N=CN=C5N6CCOCC6 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
