For research use only. Not for therapeutic Use.
Menin-MLL inhibitor 19（Cat No.:I044451）is a potent and selective small-molecule inhibitor that disrupts the interaction between menin and mixed-lineage leukemia (MLL) fusion proteins, which are key drivers in MLL-rearranged leukemias. By blocking this protein–protein interaction, the inhibitor suppresses the transcription of oncogenic target genes such as HOXA9 and MEIS1, leading to reduced proliferation and induced differentiation of leukemia cells. Menin-MLL inhibitor 19 is a valuable tool in epigenetic and cancer research, supporting the development of targeted therapies for acute leukemias with MLL rearrangements or other menin-dependent oncogenic mechanisms.
| CAS Number | 2360487-93-8 |
| Synonyms | tert-butyl N-[[1-(2-amino-2-oxoethyl)-2-oxo-3H-benzimidazol-5-yl]methyl]-N-[2-[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]-2-azaspiro[3.4]octan-6-yl]carbamate |
| Molecular Formula | C30H34F3N7O4S |
| Purity | ≥95% |
| IUPAC Name | tert-butyl N-[[1-(2-amino-2-oxoethyl)-2-oxo-3H-benzimidazol-5-yl]methyl]-N-[2-[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]-2-azaspiro[3.4]octan-6-yl]carbamate |
| InChI | InChI=1S/C30H34F3N7O4S/c1-28(2,3)44-27(43)39(12-17-4-5-22-21(8-17)37-26(42)40(22)13-23(34)41)18-6-7-29(10-18)14-38(15-29)24-20-9-19(11-30(31,32)33)45-25(20)36-16-35-24/h4-5,8-9,16,18H,6-7,10-15H2,1-3H3,(H2,34,41)(H,37,42) |
| InChIKey | FUBBZUWVZBXTGJ-UHFFFAOYSA-N |
| SMILES | CC(C)(C)OC(=O)N(CC1=CC2=C(C=C1)N(C(=O)N2)CC(=O)N)C3CCC4(C3)CN(C4)C5=C6C=C(SC6=NC=N5)CC(F)(F)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
