Melengestrol acetate

• CAT Number: R047730
• CAS Number: 2919-66-6
• Molecular Formula: C25H32O4
• Molecular Weight: 396.52
• Purity: ≥95%
• Synonyms: [(8R,9S,10R,13S,14S,17R)-17-acetyl-6,10,13-trimethyl-16-methylidene-3-oxo-1,2,8,9,11,12,14,15-octahydrocyclopenta[a]phenanthren-17-yl] acetate
• InChI: InChI=1S/C25H32O4/c1-14-11-19-20(23(5)9-7-18(28)13-21(14)23)8-10-24(6)22(19)12-15(2)25(24,16(3)26)29-17(4)27/h11,13,19-20,22H,2,7-10,12H2,1,3-6H3/t19-,20+,22+,23-,24+,25+/m1/s1
• InChIKey: UDKABVSQKJNZBH-DWNQPYOZSA-N
• SMILES: CC1=CC2C(CCC3(C2CC(=C)C3(C(=O)C)OC(=O)C)C)C4(C1=CC(=O)CC4)C

Melengestrol acetate (Cat No.: R047730) is a synthetic progestin derived from 17α-hydroxyprogesterone, widely used in veterinary medicine. It functions as a growth promoter and reproductive regulator, particularly in cattle. Administered orally as a feed additive, MGA suppresses estrus, improves feed efficiency, and promotes weight gain. Its strong binding affinity to progesterone receptors provides long-lasting effects compared to natural progesterone. Though not approved for human use, melengestrol acetate plays an important role in livestock management, ensuring controlled breeding and enhanced productivity in agricultural settings.

Reference

[1]. G M Padilla, et al. Melengestrol acetate and megestrol acetate are prostatic tumor inhibiting agents. Biochem Cell Biol. 1990 Oct;68(10):1181-8.
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[2]. G W DUNCAN, et al. BIOLOGIC EFFECTS OF MELENGESTROL ACETATE. Fertil Steril. Jul-Aug 1964;15:416-32.
[Content Brief]

[3]. https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/melengestrol-acetate