Meldrum’s Acid

• CAT Number: R010864
• CAS Number: 2033-24-1
• Molecular Formula: C6H8O4
• Molecular Weight: 144.13
• Purity: ≥95%
• Synonyms: 2,2-Dimethyl-1,3-dioxane-4,6-dione; 2,2-Propanediol Cyclic Malonate; Cyclic Isopropylidene Malonate; Isopropylidene Malonate; Meldrumic Acid; NSC 688343; NSC 71902
• Storage: -20°C
• IUPAC Name: 2,2-dimethyl-1,3-dioxane-4,6-dione
• InChI: InChI=1S/C6H8O4/c1-6(2)9-4(7)3-5(8)10-6/h3H2,1-2H3
• InChIKey: GXHFUVWIGNLZSC-UHFFFAOYSA-N
• SMILES: CC1(OC(=O)CC(=O)O1)C

Meldrum’s acid (Cat No.:R010864) is a versatile cyclic compound widely used in organic synthesis due to its highly reactive methylene group flanked by two electron-withdrawing carbonyls. It serves as a precursor for barbiturates, heterocycles, and acylating agents, and is commonly used in the synthesis of β-keto esters, aldehydes, and ketones. Meldrum’s acid readily undergoes nucleophilic substitution, condensation, and thermal decarboxylation reactions. Appearing as a white crystalline solid, it is soluble in organic solvents and plays a valuable role in synthetic strategy development, particularly in combinatorial and medicinal chemistry.