For research use only. Not for therapeutic Use.
Mecamylamine hydrochloride(CAT: R011465) is an orally active, nonselective, noncompetitive nicotinic acetylcholine receptor (nAChR) antagonist and potent ganglionic blocker capable of crossing the blood–brain barrier. It is widely used in research on neuropsychiatric disorders, hypertension, and antidepressant mechanisms. In vitro, Mecamylamine enhances firing of dorsal raphe 5-HT neurons by increasing glutamatergic and reducing GABAergic input, while also blocking histamine receptors in vascular tissue. It attenuates endothelial tube formation and suppresses choroidal neovascularization in animal models. In vivo, Mecamylamine exhibits antidepressant-like effects dependent on β2 and α7 subunits, supporting its utility in studies of mood regulation and therapeutic intervention.
| CAS Number | 826-39-1 |
| Synonyms | N,2,3,3-tetramethylbicyclo[2.2.1]heptan-2-amine;hydrochloride |
| Molecular Formula | C11H22ClN |
| Purity | ≥95% |
| IUPAC Name | N,2,3,3-tetramethylbicyclo[2.2.1]heptan-2-amine;hydrochloride |
| InChI | InChI=1S/C11H21N.ClH/c1-10(2)8-5-6-9(7-8)11(10,3)12-4;/h8-9,12H,5-7H2,1-4H3;1H |
| InChIKey | PKVZBNCYEICAQP-UHFFFAOYSA-N |
| SMILES | CC1(C2CCC(C2)C1(C)NC)C.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
