MDK7526 HCl - CAS 1448189-80-7

MDK7526 HCl (CAT: I011953) is a potent and selective protein degrader, also known as Protein degrader 1 or VHL Ligand 1. It is specifically designed to target and degrade the androgen receptor (AR). MDK7526 HCl binds to the AR and recruits the ubiquitin ligase VHL (von Hippel-Lindau) complex, leading to the ubiquitination and subsequent degradation of the AR protein. By promoting the degradation of AR, MDK7526 HCl can effectively inhibit AR-mediated signaling pathways, making it a potential therapeutic option for diseases such as prostate cancer, where the AR pathway plays a critical role.

Catalog Number: I011953

CAS Number: 1448189-80-7

Molecular Formula: C22H31ClN4O3S

Molecular Weight:467.025

Purity: ≥95%

Inventory:In stock

* For research use only. Not for human or veterinary use.


SynonymsVHL Ligand 1 (hydrochloride); Protein degrader 1 hydrochloride; MDK7526 HCl; MDK7526; MDK-7526; MDK 7526.;(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride


Molecular Formula: C22H31ClN4O3S
Molecular Weight467.025
SolubilitySoluble in DMSO
StorageStore at 0-8 °C

Computed Descriptor