McN-A-343

• CAT Number: I010403
• CAS Number: 55-45-8
• Molecular Formula: C14H18Cl2N2O2
• Molecular Weight: 317.21
• Purity: ≥95%
• Synonyms: 4-[(3-chlorophenyl)carbamoyloxy]but-2-ynyl-trimethylazanium;chloride
• InChI: InChI=1S/C14H17ClN2O2.ClH/c1-17(2,3)9-4-5-10-19-14(18)16-13-8-6-7-12(15)11-13;/h6-8,11H,9-10H2,1-3H3;1H
• InChIKey: CXFZFEJJLNLOTA-UHFFFAOYSA-N
• SMILES: C[N+](C)(C)CC#CCOC(=O)NC1=CC(=CC=C1)Cl.[Cl-]

McN-A-343（Cat No.:I010403）is a selective muscarinic acetylcholine receptor agonist, with high affinity for the M1 receptor subtype. It is commonly used in pharmacological research to study central and peripheral cholinergic signaling. McN-A-343 stimulates M1 receptor-mediated responses, including phosphoinositide hydrolysis and increased neuronal excitability, while showing limited activity at other muscarinic subtypes. It is particularly useful for investigating cognitive processes, such as learning and memory, and for evaluating potential therapeutic approaches for neurodegenerative diseases like Alzheimer’s. McN-A-343 serves as a valuable tool for probing M1-specific cholinergic functions in both in vitro and in vivo models.