Mc-Gly-Gly-Phe-Gly-PAB-OH TFA

• CAT Number: I044170
• Molecular Formula: C34H39F3N6O10
• Molecular Weight: 748.70
• Purity: ≥95%
• Synonyms: 6-(2,5-dioxopyrrol-1-yl)-N-[2-[[2-[[(2S)-1-[[2-[4-(hydroxymethyl)anilino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]hexanamide;2,2,2-trifluoroacetic acid
• InChI: InChI=1S/C32H38N6O8.C2HF3O2/c39-21-23-10-12-24(13-11-23)36-28(42)20-35-32(46)25(17-22-7-3-1-4-8-22)37-29(43)19-34-27(41)18-33-26(40)9-5-2-6-16-38-30(44)14-15-31(38)45;3-2(4,5)1(6)7/h1,3-4,7-8,10-15,25,39H,2,5-6,9,16-21H2,(H,33,40)(H,34,41)(H,35,46)(H,36,42)(H,37,43);(H,6,7)/t25-;/m0./s1
• InChIKey: DOTXLPVUMXESLK-UQIIZPHYSA-N
• SMILES: C1=CC=C(C=C1)C[C@@H](C(=O)NCC(=O)NC2=CC=C(C=C2)CO)NC(=O)CNC(=O)CNC(=O)CCCCCN3C(=O)C=CC3=O.C(=O)(C(F)(F)F)O

Mc-Gly-Gly-Phe-Gly-PAB-OH TFA（Cat No.:I044170）is a synthetic peptide-based linker commonly used in antibody-drug conjugates (ADCs) and targeted drug delivery systems. It features a methoxycinnamoyl (Mc) cap and a para-aminobenzyl (PAB) self-immolative spacer that enables controlled payload release. The Gly-Gly-Phe-Gly sequence is designed for selective cleavage by tumor-associated proteases such as cathepsin B, triggering drug release at the disease site. The TFA salt form enhances solubility and stability. This linker is valuable for constructing protease-sensitive conjugates in cancer therapy and studying controlled release mechanisms in targeted therapeutic applications.