Mc-Gly-Gly-Phe-Gly-PAB-OH

• CAT Number: I045865
• CAS Number: 2632342-05-1
• Molecular Formula: C32H38N6O8
• Molecular Weight: 634.68
• Purity: ≥95%
• Synonyms: 6-(2,5-dioxopyrrol-1-yl)-N-[2-[[2-[[(2S)-1-[[2-[4-(hydroxymethyl)anilino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]hexanamide
• InChI: InChI=1S/C32H38N6O8/c39-21-23-10-12-24(13-11-23)36-28(42)20-35-32(46)25(17-22-7-3-1-4-8-22)37-29(43)19-34-27(41)18-33-26(40)9-5-2-6-16-38-30(44)14-15-31(38)45/h1,3-4,7-8,10-15,25,39H,2,5-6,9,16-21H2,(H,33,40)(H,34,41)(H,35,46)(H,36,42)(H,37,43)/t25-/m0/s1
• InChIKey: CTYXSHFYZMWMPD-VWLOTQADSA-N
• SMILES: C1=CC=C(C=C1)C[C@@H](C(=O)NCC(=O)NC2=CC=C(C=C2)CO)NC(=O)CNC(=O)CNC(=O)CCCCCN3C(=O)C=CC3=O

Mc-Gly-Gly-Phe-Gly-PAB-OH（Cat No.:I045865）is a multifunctional peptide-based linker commonly used in the design of antibody–drug conjugates (ADCs) and targeted delivery systems. It incorporates a cleavable p-aminobenzyl (PAB) spacer and peptide sequence that is selectively recognized by proteases such as cathepsin B in tumor cells. Upon cleavage, the PAB group undergoes self-immolation, enabling efficient release of the attached payload. This controlled release mechanism enhances therapeutic precision and minimizes systemic toxicity, making Mc-Gly-Gly-Phe-Gly-PAB-OH a valuable tool in drug discovery, chemical biology, and targeted cancer research.