MBCQ

• CAT Number: M133296
• CAS Number: 150450-53-6
• Molecular Formula: C16H12ClN3O2
• Molecular Weight: 313.74
• Purity: ≥95%
• Synonyms: N-(1,3-benzodioxol-5-ylmethyl)-6-chloroquinazolin-4-amine
• InChI: InChI=1S/C16H12ClN3O2/c17-11-2-3-13-12(6-11)16(20-8-19-13)18-7-10-1-4-14-15(5-10)22-9-21-14/h1-6,8H,7,9H2,(H,18,19,20)
• InChIKey: CNODHOSDWZLJGA-UHFFFAOYSA-N
• SMILES: C1OC2=C(O1)C=C(C=C2)CNC3=NC=NC4=C3C=C(C=C4)Cl

MBCQ (Cat No.: M133296) is a selective antagonist of the P2X4 receptor, an ATP-gated ion channel implicated in neuropathic pain, neuroinflammation, and central nervous system signaling. By blocking P2X4 receptor activity, MBCQ reduces calcium influx and downstream microglial activation, making it a valuable research tool for studying pain mechanisms and neuroimmune communication. It has been used in experimental models to explore purinergic signaling in chronic pain, neurodegenerative disease, and psychiatric disorders. MBCQ provides important insights into P2X4-targeted therapeutic strategies.

Reference

[1]. Y Takase, et al. Cyclic GMP phosphodiesterase inhibitors. 2. Requirement of 6-substitution of quinazoline derivatives for potent and selective inhibitory activity. J Med Chem. 1994 Jun 24;37(13):2106-11.
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[2]. Jeffery D MacPherson, et al. Inhibition of phosphodiesterase 5 selectively reverses nitrate tolerance in the venous circulation J Pharmacol Exp Ther. 2006 Apr;317(1):188-95.
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[3]. Takeharu Kaneda, et al. Lack of cyclic nucleotide regulation of MBCQ-induced relaxation of rat ileal smooth muscle. J Smooth Muscle Res. 2003 Jun;39(3):47-54.
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