Masupirdine mesylate

• CAT Number: I018289
• CAS Number: 1791396-46-7
• Molecular Formula: C23H32BrN3O9S3
• Molecular Weight: 670.61
• Purity: ≥95%
• Synonyms: 1-(2-bromophenyl)sulfonyl-5-methoxy-3-[(4-methylpiperazin-1-yl)methyl]indole;methanesulfonic acid
• InChI: InChI=1S/C21H24BrN3O3S.2CH4O3S/c1-23-9-11-24(12-10-23)14-16-15-25(20-8-7-17(28-2)13-18(16)20)29(26,27)21-6-4-3-5-19(21)22;2*1-5(2,3)4/h3-8,13,15H,9-12,14H2,1-2H3;2*1H3,(H,2,3,4)
• InChIKey: LOZVXBFXRPRECW-UHFFFAOYSA-N
• SMILES: CN1CCN(CC1)CC2=CN(C3=C2C=C(C=C3)OC)S(=O)(=O)C4=CC=CC=C4Br.CS(=O)(=O)O.CS(=O)(=O)O

Masupirdine mesylate (Cat No.:I018289) is a selective 5-HT6 receptor antagonist developed for neurological and psychiatric disorders. The 5-HT6 receptor, expressed mainly in brain regions linked to cognition, learning, and memory, modulates neurotransmitter release including acetylcholine, dopamine, and glutamate. By blocking this receptor, masupirdine enhances cholinergic and glutamatergic signaling, showing potential in improving cognitive deficits. It has been investigated as an adjunct therapy for Alzheimer’s disease and schizophrenia. Although clinical outcomes have been mixed, masupirdine remains important for exploring serotonergic modulation in cognitive and neuropsychiatric research.