MAP4K4-IN-3

• CAT Number: I016408
• CAS Number: 1811510-58-3
• Molecular Formula: C15H12ClN5
• Molecular Weight: 297.74
• Purity: ≥95%
• Synonyms: 5-[6-amino-5-(4-chlorophenyl)pyridin-3-yl]pyrimidin-2-amine
• InChI: InChI=1S/C15H12ClN5/c16-12-3-1-9(2-4-12)13-5-10(6-19-14(13)17)11-7-20-15(18)21-8-11/h1-8H,(H2,17,19)(H2,18,20,21)
• InChIKey: KSQDIECZAQKQQW-UHFFFAOYSA-N
• SMILES: C1=CC(=CC=C1C2=C(N=CC(=C2)C3=CN=C(N=C3)N)N)Cl

MAP4K4-IN-3(CAT: I016408) is a potent and selective small-molecule inhibitor of mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4), a serine/threonine kinase implicated in diverse cellular processes including inflammation, metabolism, cytoskeletal regulation, and tumor progression. By blocking MAP4K4 activity, this compound modulates downstream signaling pathways such as JNK and NF-κB, influencing cell survival, motility, and inflammatory responses. MAP4K4-IN-3 is a valuable tool for studying the role of MAP4K4 in cancer, metabolic disorders, and inflammatory diseases. Its selectivity profile supports its use in dissecting MAP4K4-dependent signaling networks and in exploring therapeutic strategies targeting kinase-driven pathologies.