Manidipine dihydrochloride (CAT: I005342), also known as Manidipine 2HCl or CV-4093, is a dihydropyridine compound that serves as a potent calcium channel blocker. Its pharmacological action involves inhibiting Ca2+ currents with an impressive IC50 value of 2.6 nM. By blocking calcium channels, Manidipine dihydrochloride reduces the influx of calcium ions into cells, leading to vasodilation and a decrease in blood pressure. This compound’s role as a calcium channel blocker highlights its significance in cardiovascular medicine, where it offers potential therapeutic applications in the management of hypertension and other cardiovascular conditions.
| Catalog Number | I005342 |
| CAS Number | 89226-75-5 |
| Synonyms | 5-O-[2-(4-benzhydrylpiperazin-1-yl)ethyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;dihydrochloride |
| Molecular Formula | C35H40Cl2N4O6 |
| Purity | 95% |
| Target | Calcium Channel |
| Solubility | DMSO 20 mg/mL |
| Storage | 3 years -20C powder |
| IC50 | 2.6 nM |
| Reference | <p style=/line-height:25px/> |
