Manidipine dihydrochloride

• CAT Number: I005342
• CAS Number: 89226-75-5
• Molecular Formula: C35H40Cl2N4O6
• Molecular Weight: 683.62
• Purity: ≥95%
• Target: Calcium Channel
• Solubility: DMSO 20 mg/mL
• Storage: 3 years -20C powder
• IC50: 2.6 nM

Manidipine dihydrochloride (CAT: I005342), also known as Manidipine 2HCl or CV-4093, is a dihydropyridine compound that serves as a potent calcium channel blocker. Its pharmacological action involves inhibiting Ca2+ currents with an impressive IC50 value of 2.6 nM. By blocking calcium channels, Manidipine dihydrochloride reduces the influx of calcium ions into cells, leading to vasodilation and a decrease in blood pressure. This compound’s role as a calcium channel blocker highlights its significance in cardiovascular medicine, where it offers potential therapeutic applications in the management of hypertension and other cardiovascular conditions.

Reference

[1]. Buset Ríos N, Rodríguez Esparragón F, Fernández-Andrade Rodríguez C, et al. Vascular and metabolic properties of manidipine . Nefrologia. 2011;31(3):268-74.
[2]. Costa S, Zimetti F, Pedrelli M, et al. Manidipine reduces pro-inflammatory cytokines secretion in human endothelial cells and macrophages. Pharmacol Res. 2010 Sep;62(3):265-70.
[3]. Cavalieri L, Cremonesi G. Metabolic effects of manidipine. Am J Cardiovasc Drugs. 2009;9(3):163-76. doi: 10.2165/00129784-200909030-00004.
[4]. Roca-Cusachs A, Triposkiadis F. Antihypertensive effect of manidipine. Drugs. 2005;65 Suppl 2:11-9.
[5]. Nagaoka A. Pharmacologic characteristics of a new calcium antagonist, manidipine: beneficial effects on renal circulation and vascular changes. Am Heart J. 1993 Feb;125(2 Pt 2):560-5.