Malic enzyme inhibitor ME1

• CAT Number: I018120
• CAS Number: 522649-59-8
• Molecular Formula: C20H21N3O3
• Molecular Weight: 351.40
• Purity: ≥95%
• Synonyms: 3-[4-(4-hydroxyphenyl)piperazin-1-yl]-1-phenylpyrrolidine-2,5-dione
• InChI: InChI=1S/C20H21N3O3/c24-17-8-6-15(7-9-17)21-10-12-22(13-11-21)18-14-19(25)23(20(18)26)16-4-2-1-3-5-16/h1-9,18,24H,10-14H2
• InChIKey: JJFJQFJFFVLMCX-UHFFFAOYSA-N
• SMILES: C1CN(CCN1C2CC(=O)N(C2=O)C3=CC=CC=C3)C4=CC=C(C=C4)O

Malic enzyme inhibitor ME1（Cat No.:I018120）is a small-molecule compound that selectively targets malic enzyme 1 (ME1), a cytosolic NADP⁺-dependent enzyme critical for generating NADPH and supporting lipid biosynthesis, redox homeostasis, and cancer cell metabolism. By inhibiting ME1 activity, this compound disrupts metabolic flux, sensitizes tumor cells to oxidative stress, and impairs growth in malignancies reliant on NADPH production. Researchers use ME1 inhibitors to study cancer metabolism, metabolic vulnerabilities, and redox regulation. ME1 inhibitors also provide insight into developing novel therapeutic strategies targeting tumor bioenergetics.