Mal-PEG8-Boc

• CAT Number: I016303
• CAS Number: 2055048-43-4
• Molecular Formula: C27H47NO12
• Molecular Weight: 577.66
• Purity: ≥95%
• Synonyms: tert-butyl 3-[2-[2-[2-[2-[2-[2-[2-[2-(2,5-dioxopyrrol-1-yl)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
• InChI: InChI=1S/C27H47NO12/c1-27(2,3)40-26(31)6-8-32-10-12-34-14-16-36-18-20-38-22-23-39-21-19-37-17-15-35-13-11-33-9-7-28-24(29)4-5-25(28)30/h4-5H,6-23H2,1-3H3
• InChIKey: HAOLDMZFBZWLAI-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCN1C(=O)C=CC1=O

Mal-PEG8-Boc(CAT: I016303) is a heterobifunctional polyethylene glycol (PEG) linker containing a maleimide group on one end and a Boc-protected amine on the other, separated by an 8-unit PEG chain. The maleimide functionality allows highly selective conjugation with thiol groups, forming stable thioether bonds with cysteine residues in peptides, proteins, or other biomolecules. The PEG8 spacer provides hydrophilicity, flexibility, and improved solubility while minimizing steric hindrance. The Boc-protected amine serves as a latent functional group that can be deprotected under acidic conditions to reveal a free primary amine for further derivatization. This reagent is widely applied in bioconjugation, drug delivery, and biomaterials research.