Mal-PEG8-acid

• CAT Number: I017018
• CAS Number: 1818294-46-0
• Molecular Formula: C23H39NO12
• Molecular Weight: 521.56
• Purity: ≥95%
• Synonyms: 3-[2-[2-[2-[2-[2-[2-[2-[2-(2,5-dioxopyrrol-1-yl)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
• InChI: InChI=1S/C23H39NO12/c25-21-1-2-22(26)24(21)4-6-30-8-10-32-12-14-34-16-18-36-20-19-35-17-15-33-13-11-31-9-7-29-5-3-23(27)28/h1-2H,3-20H2,(H,27,28)
• InChIKey: KLZPPWOSICDUKQ-UHFFFAOYSA-N
• SMILES: C1=CC(=O)N(C1=O)CCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)O

Mal-PEG8-acid(CAT: I017018) is a heterobifunctional polyethylene glycol (PEG) linker featuring a maleimide group at one end and a carboxylic acid at the other, separated by an eight-unit PEG spacer. The maleimide moiety reacts selectively with thiols via Michael addition, enabling site-specific conjugation to cysteine residues, while the terminal carboxyl group can be coupled to primary amines or activated esters. The PEG8 spacer imparts excellent solubility, hydrophilicity, and flexibility, reducing steric hindrance in conjugation reactions. Mal-PEG8-acid is ideal for applications in protein modification, antibody–drug conjugates, PROTAC synthesis, drug delivery, and nanomaterials research, where dual reactivity and extended linker length are advantageous.