Mal-PEG6-PFP ester

• CAT Number: I016364
• CAS Number: 1599486-33-5
• Molecular Formula: C25H30F5NO10
• Molecular Weight: 599.50
• Purity: ≥95%
• Synonyms: (2,3,4,5,6-pentafluorophenyl) 3-[2-[2-[2-[2-[2-[2-(2,5-dioxopyrrol-1-yl)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
• InChI: InChI=1S/C25H30F5NO10/c26-20-21(27)23(29)25(24(30)22(20)28)41-19(34)3-5-35-7-9-37-11-13-39-15-16-40-14-12-38-10-8-36-6-4-31-17(32)1-2-18(31)33/h1-2H,3-16H2
• InChIKey: HDNANNZNASDAGQ-UHFFFAOYSA-N
• SMILES: C1=CC(=O)N(C1=O)CCOCCOCCOCCOCCOCCOCCC(=O)OC2=C(C(=C(C(=C2F)F)F)F)F

Mal-PEG6-PFP ester(CAT: I016364) is a heterobifunctional polyethylene glycol (PEG) linker designed for efficient bioconjugation. It features a maleimide group that selectively reacts with thiol-containing molecules (such as cysteine residues in peptides, proteins, or antibodies) to form stable thioether bonds, and a pentafluorophenyl (PFP) ester that reacts readily with primary amines to generate robust amide linkages. The PEG6 spacer imparts high water solubility, reduces steric hindrance, and improves flexibility, making it ideal for bridging biomolecules or modifying surfaces. This reagent is widely applied in antibody-drug conjugates, protein labeling, and advanced biomedical research requiring precise and stable molecular linkages.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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