Mal-PEG4-Val-Cit-PAB

• CAT Number: I017604
• CAS Number: 1949793-41-2
• Molecular Formula: C36H55N7O12
• Molecular Weight: 777.86
• Purity: ≥95%
• Synonyms: (2S)-5-(carbamoylamino)-2-[[(2S)-2-[3-[2-[2-[2-[2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]propanoylamino]-3-methylbutanoyl]amino]-N-[4-(hydroxymethyl)phenyl]pentanamide
• InChI: InChI=1S/C36H55N7O12/c1-25(2)33(35(50)41-28(4-3-13-39-36(37)51)34(49)40-27-7-5-26(24-44)6-8-27)42-30(46)12-16-52-18-20-54-22-23-55-21-19-53-17-14-38-29(45)11-15-43-31(47)9-10-32(43)48/h5-10,25,28,33,44H,3-4,11-24H2,1-2H3,(H,38,45)(H,40,49)(H,41,50)(H,42,46)(H3,37,39,51)/t28-,33-/m0/s1
• InChIKey: PEGLOOGTSQEDBL-UVMMSNCQSA-N
• SMILES: CC(C)C(C(=O)NC(CCCNC(=O)N)C(=O)NC1=CC=C(C=C1)CO)NC(=O)CCOCCOCCOCCOCCNC(=O)CCN2C(=O)C=CC2=O

Mal-PEG4-Val-Cit-PAB(CAT: I017604) is a widely used cleavable ADC linker containing a maleimide functional group for stable conjugation to antibody cysteine residues. Featuring a PEG4 spacer for improved solubility and flexibility, the Val-Cit dipeptide ensures selective cleavage by intracellular cathepsin B, while the para-aminobenzyl (PAB) self-immolative spacer enables efficient payload release. This design provides stability in systemic circulation with precise intracellular drug liberation, making it an essential component for antibody–drug conjugate (ADC) synthesis. Mal-PEG4-Val-Cit-PAB is widely employed in developing next-generation targeted cancer therapies, serving as a robust platform for studying ADC linker–payload optimization.