Mal-PEG2-Val-Cit-PABA

• CAT Number: I045125
• CAS Number: 1662687-83-3
• Molecular Formula: C27H38N6O9
• Molecular Weight: 590.63
• Purity: ≥95%
• Synonyms: 2-[2-(2,5-dioxopyrrol-1-yl)ethoxy]ethyl N-[(2S)-1-[[(2S)-5-(carbamoylamino)-1-[4-(hydroxymethyl)anilino]-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate
• InChI: InChI=1S/C27H38N6O9/c1-17(2)23(32-27(40)42-15-14-41-13-12-33-21(35)9-10-22(33)36)25(38)31-20(4-3-11-29-26(28)39)24(37)30-19-7-5-18(16-34)6-8-19/h5-10,17,20,23,34H,3-4,11-16H2,1-2H3,(H,30,37)(H,31,38)(H,32,40)(H3,28,29,39)/t20-,23-/m0/s1
• InChIKey: HTNGHIKQRXTBSP-REWPJTCUSA-N
• SMILES: CC(C)[C@@H](C(=O)N[C@@H](CCCNC(=O)N)C(=O)NC1=CC=C(C=C1)CO)NC(=O)OCCOCCN2C(=O)C=CC2=O

Mal-PEG2-Val-Cit-PABA（Cat No.:I045125）is a cleavable linker used in the design of antibody–drug conjugates (ADCs) to enable targeted drug delivery. It combines a maleimide group (Mal) for conjugation to antibody thiols, a PEG2 spacer to enhance solubility and flexibility, and a Val-Cit dipeptide sequence cleavable by cathepsin B—an enzyme overexpressed in tumor cells. Upon cleavage, the PABA (para-aminobenzyl alcohol) self-immolative spacer releases the cytotoxic payload. This linker system allows for stable circulation and controlled intracellular drug release. Supplied for research into ADC development, targeted cancer therapy, and drug delivery technologies.