For research use only. Not for therapeutic Use.
Mal-PEG2-oxyamine TFA(CAT: I040224) is a PEG-based heterobifunctional linker commonly used in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It features a maleimide group for conjugation with thiol-containing molecules and an oxyamine group for coupling with aldehyde or ketone functionalities. This two-carbon PEG spacer provides optimal flexibility and solubility, facilitating the spatial arrangement required for efficient ternary complex formation. In PROTAC design, such linkers connect an E3 ligase ligand with a target protein ligand, enabling selective protein degradation via the ubiquitin-proteasome system. Mal-PEG2-oxyamine TFA is ideal for customizable linker strategies in targeted protein degradation research.
| Synonyms | 1-[2-[2-(2-aminooxyethoxy)ethoxy]ethyl]pyrrole-2,5-dione;2,2,2-trifluoroacetic acid |
| Molecular Formula | C12H17F3N2O7 |
| Purity | ≥95% |
| IUPAC Name | 1-[2-[2-(2-aminooxyethoxy)ethoxy]ethyl]pyrrole-2,5-dione;2,2,2-trifluoroacetic acid |
| InChI | InChI=1S/C10H16N2O5.C2HF3O2/c11-17-8-7-16-6-5-15-4-3-12-9(13)1-2-10(12)14;3-2(4,5)1(6)7/h1-2H,3-8,11H2;(H,6,7) |
| InChIKey | NCWSUMIVBVTGLK-UHFFFAOYSA-N |
| SMILES | C1=CC(=O)N(C1=O)CCOCCOCCON.C(=O)(C(F)(F)F)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
