Mal-N-bis(PEG4-C2-acid)

• CAT Number: I015930
• CAS Number: 2100306-52-1
• Molecular Formula: C29H48N2O15
• Molecular Weight: 664.70
• Purity: ≥95%
• Synonyms: 3-[2-[2-[2-[2-[2-[2-[2-[2-(2-carboxyethoxy)ethoxy]ethoxy]ethoxy]ethyl-[3-(2,5-dioxopyrrol-1-yl)propanoyl]amino]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
• InChI: InChI=1S/C29H48N2O15/c32-25(3-6-31-26(33)1-2-27(31)34)30(7-11-41-15-19-45-23-21-43-17-13-39-9-4-28(35)36)8-12-42-16-20-46-24-22-44-18-14-40-10-5-29(37)38/h1-2H,3-24H2,(H,35,36)(H,37,38)
• InChIKey: FBUVDGNGWRGLFH-UHFFFAOYSA-N
• SMILES: C1=CC(=O)N(C1=O)CCC(=O)N(CCOCCOCCOCCOCCC(=O)O)CCOCCOCCOCCOCCC(=O)O

Mal-N-bis(PEG4-C2-acid)（Cat No.:I015930）is a heterobifunctional PEG-based crosslinker featuring a maleimide group and two terminal carboxylic acids, each connected through PEG₄-C₂ linkers. The maleimide moiety reacts selectively with thiol groups under mild physiological conditions, forming stable thioether bonds, while the carboxyl groups can be activated for conjugation with primary amines or hydroxyls. The PEG₄-C₂ chains enhance solubility, flexibility, and biocompatibility, while reducing steric hindrance. This versatile reagent is widely used in bioconjugation, dual-site crosslinking, nanoparticle functionalization, and advanced drug delivery systems that require stable and hydrophilic linkages.