For research use only. Not for therapeutic Use.
Mal-amido-PEG2-Val-Cit-PAB-PNP（Cat No.:I016102）is a heterobifunctional linker widely applied in the development of antibody–drug conjugates (ADCs). It features a maleimide (Mal) group for stable thiol conjugation, a PEG2 spacer that enhances solubility, and a Val-Cit dipeptide serving as a cathepsin-cleavable linker for tumor-selective drug release. The para-aminobenzyl (PAB) unit ensures efficient self-immolative drug release, while the p-nitrophenyl (PNP) ester enables effective coupling to hydroxyl or amine groups. This multifunctional design provides controlled, site-specific bioconjugation, making it a critical tool in targeted therapeutics, chemical biology, and ADC synthesis.
| CAS Number | 2112738-13-1 |
| Synonyms | [4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[3-[2-[2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]ethoxy]ethoxy]propanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl (4-nitrophenyl) carbonate |
| Molecular Formula | C39H50N8O14 |
| Purity | ≥95% |
| IUPAC Name | [4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[3-[2-[2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]ethoxy]ethoxy]propanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl (4-nitrophenyl) carbonate |
| InChI | InChI=1S/C39H50N8O14/c1-25(2)35(45-32(49)16-20-58-22-23-59-21-18-41-31(48)15-19-46-33(50)13-14-34(46)51)37(53)44-30(4-3-17-42-38(40)54)36(52)43-27-7-5-26(6-8-27)24-60-39(55)61-29-11-9-28(10-12-29)47(56)57/h5-14,25,30,35H,3-4,15-24H2,1-2H3,(H,41,48)(H,43,52)(H,44,53)(H,45,49)(H3,40,42,54)/t30-,35-/m0/s1 |
| InChIKey | PAGAOQLHMRBQFV-QGRQJHSQSA-N |
| SMILES | CC(C)[C@@H](C(=O)N[C@@H](CCCNC(=O)N)C(=O)NC1=CC=C(C=C1)COC(=O)OC2=CC=C(C=C2)[N+](=O)[O-])NC(=O)CCOCCOCCNC(=O)CCN3C(=O)C=CC3=O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
