Magnesium L-Threonate

• CAT Number: I031464
• CAS Number: 778571-57-6
• Molecular Formula: C8H14MgO10
• Molecular Weight: 294.5
• Purity: 98%
• Synonyms: Magnesium L-Threonate
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: Magnesium (2R,3S)-2,3,4-trihydroxybutanoate
• InChI: InChI=1S/2C4H8O5.Mg/c2*5-1-2(6)3(7)4(8)9;/h2*2-3,5-7H,1H2,(H,8,9);/q;;+2/p-2/t2*2-,3+;/m00./s1
• InChIKey: YVJOHOWNFPQSPP-BALCVSAKSA-L
• SMILES: O=C([O-])[C@H](O)[C@@H](O)CO.O=C([O-])[C@H](O)[C@@H](O)CO.[Mg+2]

Magnesium L-Threonate(CAT: I031464) is a magnesium supplement that has gained attention for its potential cognitive benefits. Magnesium L-Threonate is a form of magnesium that is highly absorbable and can cross the blood-brain barrier, allowing it to potentially enhance brain function. Some studies suggest that it may improve memory and learning ability, as well as reduce symptoms of anxiety and depression.

Reference

1: Xu T, Li D, Zhou X, Ouyang HD, Zhou LJ, Zhou H, Zhang HM, Wei XH, Liu G, Liu XG. Oral Application of Magnesium-L-Threonate Attenuates Vincristine-induced Allodynia and Hyperalgesia by Normalization of Tumor Necrosis Factor-α/Nuclear Factor-κB Signaling. Anesthesiology. 2017 Jun;126(6):1151-1168. doi: 10.1097/ALN.0000000000001601. PubMed PMID: 28306698.
2: Wang J, Liu Y, Zhou LJ, Wu Y, Li F, Shen KF, Pang RP, Wei XH, Li YY, Liu XG. Magnesium L-threonate prevents and restores memory deficits associated with neuropathic pain by inhibition of TNF-α. Pain Physician. 2013 Sep-Oct;16(5):E563-75. PubMed PMID: 24077207.
3: Mickley GA, Hoxha N, Luchsinger JL, Rogers MM, Wiles NR. Chronic dietary magnesium-L-threonate speeds extinction and reduces spontaneous recovery of a conditioned taste aversion. Pharmacol Biochem Behav. 2013 May;106:16-26. doi: 10.1016/j.pbb.2013.02.019. Epub 2013 Mar 6. PubMed PMID: 23474371; PubMed Central PMCID: PMC3668337.