For research use only. Not for therapeutic Use.
MAGL-IN-4 (Cat No.: I045378) is a potent and selective inhibitor of monoacylglycerol lipase (MAGL), the key enzyme responsible for hydrolyzing 2-arachidonoylglycerol (2-AG), an endocannabinoid involved in pain, inflammation, and neuroprotection. By inhibiting MAGL, MAGL-IN-4 increases 2-AG levels, enhancing endocannabinoid signaling while reducing pro-inflammatory arachidonic acid metabolites. This dual action makes it a valuable research tool for studying the endocannabinoid system and its therapeutic potential in conditions such as chronic pain, neurodegenerative diseases, and cancer. MAGL-IN-4 is primarily used in preclinical studies.
| CAS Number | 2135785-20-3 |
| Synonyms | 2-[3-[(3-chloro-4-methylphenyl)methoxy]azetidine-1-carbonyl]-7-oxa-5-azaspiro[3.4]octan-6-one |
| Molecular Formula | C18H21ClN2O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C18H21ClN2O4/c1-11-2-3-12(4-15(11)19)9-24-14-7-21(8-14)16(22)13-5-18(6-13)10-25-17(23)20-18/h2-4,13-14H,5-10H2,1H3,(H,20,23) |
| InChIKey | AKBHYCHPWZPGAH-UHFFFAOYSA-N |
| SMILES | CC1=C(C=C(C=C1)COC2CN(C2)C(=O)C3CC4(C3)COC(=O)N4)Cl |
| Reference | [1]. Shuhei Ikeda, et al. Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3-Oxo-3,4-dihydro-2 H-benzo[ b][1,4]oxazin-6-yl Moiety. J Med Chem. 2021 Aug 12;64(15 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
