For research use only. Not for therapeutic Use.
Macropa-NH2 TFA (Cat No.: I045618) is a trifluoroacetate salt form of the bifunctional chelator Macropa functionalized with an amine group. Designed for strong and selective coordination of actinium-225 and other large trivalent radiometals, it is widely applied in targeted alpha therapy (TAT) research. The pendant amine enables facile conjugation to biomolecules such as antibodies or peptides, facilitating the development of radiopharmaceuticals. Macropa-NH2 TFA provides a robust platform for studying chelation chemistry, radiometal stability, and the design of targeted radiotherapeutics for cancer treatment.
| CAS Number | 2705054-08-4 |
| Synonyms | 4-amino-6-[[16-[(6-carboxypyridin-2-yl)methyl]-1,4,10,13-tetraoxa-7,16-diazacyclooctadec-7-yl]methyl]pyridine-2-carboxylic acid;2,2,2-trifluoroacetic acid |
| Molecular Formula | C28H38F3N5O10 |
| Purity | ≥95% |
| InChI | InChI=1S/C26H37N5O8.C2HF3O2/c27-20-16-22(29-24(17-20)26(34)35)19-31-6-10-38-14-12-36-8-4-30(5-9-37-13-15-39-11-7-31)18-21-2-1-3-23(28-21)25(32)33;3-2(4,5)1(6)7/h1-3,16-17H,4-15,18-19H2,(H2,27,29)(H,32,33)(H,34,35);(H,6,7) |
| InChIKey | ZDYLMJRUTNAJBE-UHFFFAOYSA-N |
| SMILES | C1COCCOCCN(CCOCCOCCN1CC2=NC(=CC=C2)C(=O)O)CC3=NC(=CC(=C3)N)C(=O)O.C(=O)(C(F)(F)F)O |
| Reference | [1]. Thiele NA, et al. An Eighteen-Membered Macrocyclic Ligand for Actinium-225 Targeted Alpha Therapy. Angew Chem Int Ed Engl. 2017;56(46):14712-14717. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
