For research use only. Not for therapeutic Use.
M2698 (cat: I016701 is an orally active, ATP-competitive, and selective dual inhibitor of p70S6K and Akt kinases, with IC₅₀ values of 1 nM for p70S6K, Akt1, and Akt3. It crosses the blood–brain barrier and exhibits potent anticancer activity. In breast cancer cell lines, M2698 suppresses proliferation (IC₅₀ = 0.02–8.5 μM), inhibits p70S6K activity, and suppresses Akt signaling despite feedback phosphorylation. It also inhibits downstream markers including pGSK3β (IC₅₀ = 17 nM) and pS6 (IC₅₀ = 15 nM). Oral dosing in tumor models reduces growth in a dose-dependent manner and induces regression at 30 mg/kg. M2698 is valuable for oncology and signal transduction research.
| CAS Number | 1379545-95-5 |
| Synonyms | 4-[[(1S)-2-(azetidin-1-yl)-1-[4-chloro-3-(trifluoromethyl)phenyl]ethyl]amino]quinazoline-8-carboxamide |
| Molecular Formula | C21H19ClF3N5O |
| Purity | ≥95% |
| IUPAC Name | 4-[[(1S)-2-(azetidin-1-yl)-1-[4-chloro-3-(trifluoromethyl)phenyl]ethyl]amino]quinazoline-8-carboxamide |
| InChI | InChI=1S/C21H19ClF3N5O/c22-16-6-5-12(9-15(16)21(23,24)25)17(10-30-7-2-8-30)29-20-14-4-1-3-13(19(26)31)18(14)27-11-28-20/h1,3-6,9,11,17H,2,7-8,10H2,(H2,26,31)(H,27,28,29)/t17-/m1/s1 |
| InChIKey | HXAUJHZZPCBFPN-QGZVFWFLSA-N |
| SMILES | C1CN(C1)CC(C2=CC(=C(C=C2)Cl)C(F)(F)F)NC3=NC=NC4=C3C=CC=C4C(=O)N |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
