m-PEG8-O-alkyne

• CAT Number: I016181
• CAS Number: 880081-81-2
• Molecular Formula: C20H38O9
• Molecular Weight: 422.51
• Purity: ≥95%
• Synonyms: 3-[2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]prop-1-yne
• InChI: InChI=1S/C20H38O9/c1-3-4-22-7-8-24-11-12-26-15-16-28-19-20-29-18-17-27-14-13-25-10-9-23-6-5-21-2/h1H,4-20H2,2H3
• InChIKey: XQINQERKXPDHFU-UHFFFAOYSA-N
• SMILES: COCCOCCOCCOCCOCCOCCOCCOCCOCC#C

m-PEG8-O-alkyne（Cat No.:I016181）is a monofunctional PEG-based linker designed for efficient click chemistry and bioconjugation. It features a terminal alkyne group that undergoes copper-catalyzed or strain-promoted azide–alkyne cycloaddition (CuAAC or SPAAC), enabling selective and stable modification with azide-containing molecules. The PEG8 spacer provides excellent aqueous solubility, flexibility, and reduced steric hindrance, making it suitable for complex biomolecular and polymer systems. The methoxy end group ensures stability while maintaining monofunctionality. This reagent is widely applied in drug delivery, diagnostic probe development, imaging, and chemical biology research requiring hydrophilic alkyne-functionalized linkers.