m-PEG5-NH2

• CAT Number: I014484
• CAS Number: 5498-83-9
• Molecular Formula: C11H25NO5
• Molecular Weight: 251.32
• Purity: ≥95%
• Synonyms: 2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethanamine
• InChI: InChI=1S/C11H25NO5/c1-13-4-5-15-8-9-17-11-10-16-7-6-14-3-2-12/h2-12H2,1H3
• InChIKey: WGQYVGMCDPUCEJ-UHFFFAOYSA-N
• SMILES: COCCOCCOCCOCCOCCN

m-PEG5-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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