m-PEG3-succinimidyl carbonate

  • CAT Number: I016645
  • CAS Number: 477775-77-2
  • Molecular Formula: C₁₂H₁₉NO₈
  • Molecular Weight: 305.28
  • Purity: ≥95%
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m-PEG3-succinimidyl carbonate (CAT: I016645) serves as a PEG-based PROTAC linker, playing a vital role in the synthesis of Proteolysis-Targeting Chimeras (PROTACs). These innovative molecules are designed to selectively degrade disease-associated proteins within cells. As a linker, m-PEG3-succinimidyl carbonate facilitates the conjugation of the ligand that binds to the target protein with the ligand that recruits an E3 ubiquitin ligase, triggering protein degradation.

Catalog Number I016645
CAS Number 477775-77-2
Molecular Formula

C₁₂H₁₉NO₈

Purity 95%
Reference

[1]. Miller MA, et al. Amphiphilic conjugates of human brain natriuretic peptide designed for oral delivery: in vitro activity screening. Bioconjug Chem. 2006 Mar-Apr;17(2):267-74.

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