m-PEG3-succinimidyl carbonate (CAT: I016645) serves as a PEG-based PROTAC linker, playing a vital role in the synthesis of Proteolysis-Targeting Chimeras (PROTACs). These innovative molecules are designed to selectively degrade disease-associated proteins within cells. As a linker, m-PEG3-succinimidyl carbonate facilitates the conjugation of the ligand that binds to the target protein with the ligand that recruits an E3 ubiquitin ligase, triggering protein degradation.
| Catalog Number | I016645 |
| CAS Number | 477775-77-2 |
| Molecular Formula | C₁₂H₁₉NO₈ |
| Purity | 95% |
| Reference | [1]. Miller MA, et al. Amphiphilic conjugates of human brain natriuretic peptide designed for oral delivery: in vitro activity screening. Bioconjug Chem. 2006 Mar-Apr;17(2):267-74. |
