m-PEG3-Aminooxy

• CAT Number: I014053
• CAS Number: 248275-10-7
• Molecular Formula: C7H17NO4
• Molecular Weight: 179.21
• Purity: ≥95%
• Synonyms: O-[2-[2-(2-methoxyethoxy)ethoxy]ethyl]hydroxylamine
• InChI: InChI=1S/C7H17NO4/c1-9-2-3-10-4-5-11-6-7-12-8/h2-8H2,1H3
• InChIKey: UPZRLQLRXOQKOM-UHFFFAOYSA-N
• SMILES: COCCOCCOCCON

m-PEG3-Aminooxy is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Reference

[1]. Luo W, et al. Tailored electroactive and quantitative ligand density microarrays applied to stem cell differentiation. J Am Chem Soc. 2010 Mar 3;132(8):2614-21.
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