m-PEG3-aldehyde

• CAT Number: I017152
• CAS Number: 356066-46-1
• Molecular Formula: C8H16O4
• Molecular Weight: 176.21
• Purity: ≥95%
• Synonyms: 3-[2-(2-methoxyethoxy)ethoxy]propanal
• InChI: InChI=1S/C8H16O4/c1-10-5-6-12-8-7-11-4-2-3-9/h3H,2,4-8H2,1H3
• InChIKey: OBRBOVOZENLKGQ-UHFFFAOYSA-N
• SMILES: COCCOCCOCCC=O

m-PEG3-aldehyde(CAT: I017152) is a monofunctional polyethylene glycol (PEG) derivative featuring a terminal aldehyde group connected through a short triethylene glycol (PEG3) spacer. The reactive aldehyde allows efficient conjugation with primary amines and hydrazides via Schiff base formation or reductive amination, enabling stable covalent linkage to biomolecules and surfaces. The PEG3 backbone provides hydrophilicity, flexibility, and reduced steric hindrance, supporting high reaction efficiency in aqueous environments. m-PEG3-aldehyde is widely used in protein and peptide modification, drug delivery systems, surface functionalization, and biomaterials engineering, where controlled PEGylation and site-specific conjugation are required to enhance solubility, stability, and biocompatibility.

Reference

[1]. Saifer MG, et al.Selectivity of binding of PEGs and PEG-like oligomers to anti-PEG antibodies induced by methoxyPEG-proteins.Mol Immunol. 2014 Feb;57(2):236-46.
[Content Brief]